diff --git a/Dockerfile b/Dockerfile
index 61676675..b7c8658a 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -75,6 +75,7 @@ ENV HOST=0.0.0.0
 ENV INSECURE=false
 ENV INIT_ENABLED=false
 ENV DISABLE_IPV6=false
+ENV WG_INTERFACE=wg0
 
 LABEL org.opencontainers.image.source=https://github.com/wg-easy/wg-easy
 
diff --git a/src/server/database/sqlite.ts b/src/server/database/sqlite.ts
index bae94133..7f4086fe 100644
--- a/src/server/database/sqlite.ts
+++ b/src/server/database/sqlite.ts
@@ -20,6 +20,7 @@ const db = drizzle({ client, schema });
 
 export async function connect() {
   await migrate();
+  await normalizeInterfaceName(db);
   const dbService = new DBService(db);
 
   if (WG_INITIAL_ENV.ENABLED) {
@@ -120,12 +121,46 @@ async function initialSetup(db: DBServiceType) {
   }
 }
 
+/**
+ * Replaces hardcoded 'wg0' in the stored iptables hook commands with the
+ * actual WG_INTERFACE name. Runs after migration so fresh installs that use a
+ * non-default interface (e.g. wg1) get the correct interface name in their
+ * PostUp/PostDown rules. Idempotent when WG_INTERFACE=wg0.
+ */
+async function normalizeInterfaceName(db: DBType) {
+  const iface = WG_ENV.WG_INTERFACE;
+  if (iface === 'wg0') return;
+
+  DB_DEBUG(`Normalizing interface name 'wg0' -> '${iface}' in hooks...`);
+
+  await db.transaction(async (tx) => {
+    const hooks = await tx.query.hooks
+      .findFirst({ where: eq(schema.hooks.id, 'wg0') });
+
+    if (!hooks) return;
+
+    const needsUpdate =
+      hooks.postUp.includes('wg0') || hooks.postDown.includes('wg0');
+
+    if (needsUpdate) {
+      await tx
+        .update(schema.hooks)
+        .set({
+          postUp: hooks.postUp.replaceAll('wg0', iface),
+          postDown: hooks.postDown.replaceAll('wg0', iface),
+        })
+        .where(eq(schema.hooks.id, 'wg0'))
+        .execute();
+      DB_DEBUG(`Interface name normalized to '${iface}' in hooks.`);
+    }
+  });
+}
+
 async function disableIpv6(db: DBType) {
-  // This should match the initial value migration
-  const postUpMatch =
-    ' ip6tables -t nat -A POSTROUTING -s {{ipv6Cidr}} -o {{device}} -j MASQUERADE; ip6tables -A INPUT -p udp -m udp --dport {{port}} -j ACCEPT; ip6tables -A FORWARD -i wg0 -j ACCEPT; ip6tables -A FORWARD -o wg0 -j ACCEPT;';
-  const postDownMatch =
-    ' ip6tables -t nat -D POSTROUTING -s {{ipv6Cidr}} -o {{device}} -j MASQUERADE; ip6tables -D INPUT -p udp -m udp --dport {{port}} -j ACCEPT; ip6tables -D FORWARD -i wg0 -j ACCEPT; ip6tables -D FORWARD -o wg0 -j ACCEPT;';
+  const iface = WG_ENV.WG_INTERFACE;
+  // This should match the initial value migration (after normalizeInterfaceName runs)
+  const postUpMatch = ` ip6tables -t nat -A POSTROUTING -s {{ipv6Cidr}} -o {{device}} -j MASQUERADE; ip6tables -A INPUT -p udp -m udp --dport {{port}} -j ACCEPT; ip6tables -A FORWARD -i ${iface} -j ACCEPT; ip6tables -A FORWARD -o ${iface} -j ACCEPT;`;
+  const postDownMatch = ` ip6tables -t nat -D POSTROUTING -s {{ipv6Cidr}} -o {{device}} -j MASQUERADE; ip6tables -D INPUT -p udp -m udp --dport {{port}} -j ACCEPT; ip6tables -D FORWARD -i ${iface} -j ACCEPT; ip6tables -D FORWARD -o ${iface} -j ACCEPT;`;
 
   await db.transaction(async (tx) => {
     const hooks = await tx.query.hooks.findFirst({
diff --git a/src/server/utils/config.ts b/src/server/utils/config.ts
index 322b7ae6..ed5a41fc 100644
--- a/src/server/utils/config.ts
+++ b/src/server/utils/config.ts
@@ -38,6 +38,8 @@ export const WG_ENV = {
   /** If IPv6 should be disabled */
   DISABLE_IPV6: process.env.DISABLE_IPV6 === 'true',
   WG_EXECUTABLE: await detectAwg(),
+  /** WireGuard interface name. Allows running multiple wg-easy instances on the same host. */
+  WG_INTERFACE: process.env.WG_INTERFACE ?? 'wg0',
 };
 
 export const WG_INITIAL_ENV = {
diff --git a/src/server/utils/ip.ts b/src/server/utils/ip.ts
index c3c097e1..54ecc41c 100644
--- a/src/server/utils/ip.ts
+++ b/src/server/utils/ip.ts
@@ -93,7 +93,7 @@ function getPrivateInformation() {
   const obj: Record<string, { ipv4: string[]; ipv6: string[] }> = {};
 
   for (const name of interfaceNames) {
-    if (name === 'wg0') {
+    if (name === WG_ENV.WG_INTERFACE) {
       continue;
     }