diff --git a/fastapi/dependencies/utils.py b/fastapi/dependencies/utils.py
index 84dfa4d03..3bdc27a7a 100644
--- a/fastapi/dependencies/utils.py
+++ b/fastapi/dependencies/utils.py
@@ -255,7 +255,7 @@ def get_typed_return_annotation(call: Callable[..., Any]) -> Any:
     signature = inspect.signature(call)
     annotation = signature.return_annotation
 
-    if annotation is inspect.Signature.empty:
+    if annotation == "None" or annotation is inspect.Signature.empty:
         return None
 
     globalns = getattr(call, "__globals__", {})
diff --git a/tests/test_return_none_future_annotations.py b/tests/test_return_none_future_annotations.py
new file mode 100644
index 000000000..86f2deeb7
--- /dev/null
+++ b/tests/test_return_none_future_annotations.py
@@ -0,0 +1,26 @@
+from __future__ import annotations
+
+import http
+import logging
+
+from fastapi import APIRouter, FastAPI
+from fastapi.testclient import TestClient
+
+router = APIRouter()
+
+app = FastAPI()
+
+
+@router.get("/no-content", status_code=http.HTTPStatus.NO_CONTENT)
+def return_no_content() -> None:
+    logging.info("endpoint called")
+
+
+app.include_router(router)
+
+client = TestClient(app)
+
+
+def test_no_content():
+    response = client.get("/no-content")
+    assert response.status_code == http.HTTPStatus.NO_CONTENT, response.text